Postdoctoral Researcher position in the Laboratory of Structural Biology
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Offer Description Laboratory of Structural Biology at the International Institute of Molecular and Cell Biology in Warsaw, headed by Prof. Matthias Bochtler is looking for a Postdoctoral Researcher . The candidate will join the project entitled ““Stealth” asparaginases as improved protein drugs for the treatment of childhood acute lymphoblastic leukemia” funded by the Opus grant (2024/53/B/NZ1/01841) of the National Science Centre, Poland led by prof. Matthias Bochtler. The project aims to develop 'stealth' asparaginases for the treatment of acute lymphoblastic leukemia (ALL). Asparaginases are currently used in ALL therapy. This treatment is based on the observation that malignant clones tend to lose the ability to synthesize asparagine in a cell-autonomous manner, becoming dependent on asparagine from the serum. Currently, the preferred choice of asparaginase is Oncaspar, a pegylated form of Escherichia coli asparaginase. In children, Oncaspar treatment triggers immune hypersensitivity in approximately half of cases. Genetic association studies show that the risk of a hypersensitivity reaction is dependent on the haplotype and is significantly higher for certain MHC-II haplotypes.
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